# Randall K. Saiki — Patents explained on PatentBrief

Randall K. Saiki has 4 landmark patents explained in plain English on PatentBrief.

- [How an Enzyme Helps Find Specific DNA in a Sample](https://patentbrief.org/patent/us/5210015/hcv-pcr-detection) — granted 1993
  This patent describes a method for detecting a specific DNA sequence in a sample by using a labeled DNA probe and an enzyme that cuts the probe, releasing detectable fragments.
- [How to Make Many Copies of a DNA Piece with Heat](https://patentbrief.org/patent/us/4965188/taq-polymerase-for-pcr) — granted 1990
  This patent describes the Polymerase Chain Reaction (PCR) method, a technique to make millions of copies of a specific DNA segment using a heat-resistant enzyme and repeated temperature changes.
- [Detecting Genetic Differences Using DNA Probes and Enzymes](https://patentbrief.org/patent/us/4683194/pcr-process) — granted 1987
  This 1987 patent describes a method to find tiny differences in DNA sequences by using special DNA pieces (probes) and cutting enzymes, which can help diagnose genetic conditions like sickle cell anemia.
- [How to Make Billions of Copies of a DNA Segment](https://patentbrief.org/patent/us/4683195/pcr-polymerase-chain-reaction) — granted 1987
  This patent describes the Polymerase Chain Reaction (PCR), a method to rapidly create many copies of a specific piece of DNA or RNA, enabling its detection and analysis.

**Full profile:** https://patentbrief.org/inventor/randall-k-saiki

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_Source: PatentBrief — https://patentbrief.org. Plain-English explanations of US patents._