# Leonard G. Presta — Patents explained on PatentBrief

Leonard G. Presta has 4 landmark patents explained in plain English on PatentBrief.

- [How Engineered Antibodies Target TGF-beta Proteins to Fight Cancer](https://patentbrief.org/patent/us/7527791/ipilimumab-yervoy) — granted 2009
  This patent describes specific engineered antibodies, made from mouse and human parts, designed to block TGF-beta proteins to help treat various cancers like breast or lung cancer.
- [How Genentech's Antibodies Stop Tumor Blood Vessel Growth](https://patentbrief.org/patent/us/7297334/anti-cd20-antibody-therapy) — granted 2007
  A Genentech patent for specific lab-made antibodies that block a protein called VEGF, effectively starving tumors of the blood supply they need to grow.
- [How Genentech Engineered Antibodies to Starve Tumors of Blood](https://patentbrief.org/patent/us/7169901/avastin-bevacizumab) — granted 2007
  A 2007 Genentech patent describing specific lab-made antibodies that block a protein called VEGF, which tumors use to grow new blood vessels.
- [How to Redesign Mouse Antibodies for Safe Use in Humans](https://patentbrief.org/patent/us/6054297/rituxan-chop-chemotherapy) — granted 2000
  Genentech's 1995 patent on a systematic method for humanizing rodent antibodies by grafting their disease-targeting loops onto a human consensus framework while carefully swapping key structural support residues to maintain binding strength.

**Full profile:** https://patentbrief.org/inventor/leonard-g-presta

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_Source: PatentBrief — https://patentbrief.org. Plain-English explanations of US patents._