# Jose Ramon Corvalan — Patents explained on PatentBrief

Jose Ramon Corvalan has 1 landmark patent explained in plain English on PatentBrief.

- [How Human Antibodies Block the Immune System's Off-Switch](https://patentbrief.org/patent/us/6682736/enbrel-etanercept) — granted 2004
  Abgenix's 1999 patent on fully human monoclonal antibodies that bind to CTLA-4, a protein brake on the immune system, allowing T-cells to stay active and attack cancer cells.

**Full profile:** https://patentbrief.org/inventor/jose-ramon-corvalan

---

_Source: PatentBrief — https://patentbrief.org. Plain-English explanations of US patents._