# Genentech Inc — Patents explained on PatentBrief

Genentech Inc has 13 landmark patents explained in plain English on PatentBrief.

- [How Genentech's Antibody Targets Cancerous B Cells](https://patentbrief.org/patent/us/9845355/tecentriq-atezolizumab) — granted 2017
  This patent describes a specific humanized antibody designed to bind to a protein called CD79b, which is found on the surface of certain cancer cells.
- [How Genentech Engineered Antibodies to Block the Bv8 Protein](https://patentbrief.org/patent/us/9266948/kadcyla-t-dm1) — granted 2016
  This patent details specific genetic blueprints for creating antibodies that target and neutralize Bv8, a protein often associated with tumor growth and inflammation.
- [How Antibodies Can Force Cancer Cells to Self-Destruct](https://patentbrief.org/patent/us/7807153/avastin-chemotherapy) — granted 2010
  Genentech's patent on specific antibodies that bind to the Apo-2 receptor to trigger programmed cell death in cancer cells.
- [How Engineered Antibodies Target TGF-beta Proteins to Fight Cancer](https://patentbrief.org/patent/us/7527791/ipilimumab-yervoy) — granted 2009
  This patent describes specific engineered antibodies, made from mouse and human parts, designed to block TGF-beta proteins to help treat various cancers like breast or lung cancer.
- [How Genentech's Antibodies Stop Tumor Blood Vessel Growth](https://patentbrief.org/patent/us/7297334/anti-cd20-antibody-therapy) — granted 2007
  A Genentech patent for specific lab-made antibodies that block a protein called VEGF, effectively starving tumors of the blood supply they need to grow.
- [How Genentech Engineered Antibodies to Starve Tumors of Blood](https://patentbrief.org/patent/us/7169901/avastin-bevacizumab) — granted 2007
  A 2007 Genentech patent describing specific lab-made antibodies that block a protein called VEGF, which tumors use to grow new blood vessels.
- [How Genentech Created Antibodies to Stop Tumor Growth](https://patentbrief.org/patent/us/6884879/anti-vegf-antibodies) — granted 2005
  A 1997 patent describing a specific humanized antibody designed to block VEGF, a protein that helps tumors grow their own blood supply.
- [How Genentech Created Antibodies to Target Prostate Cancer Cells](https://patentbrief.org/patent/us/6824780/avastin-dosing) — granted 2004
  A patent describing specific antibodies that latch onto and kill cancer cells expressing the PSCA protein, effectively turning the body's immune-targeting tools into cancer-fighting weapons.
- [How Genentech Purifies Therapeutic Antibodies for Cancer Treatment](https://patentbrief.org/patent/us/6339142/rituxan-rituximab) — granted 2002
  A method for refining mixtures of anti-HER2 antibodies to ensure that harmful acidic variants remain below 25 percent of the total composition.
- [Making High-Concentration Antibody Medicines Stable for Injection](https://patentbrief.org/patent/us/6267958/rituxan-chop) — granted 2001
  Genentech's 2001 patent on a method to create stable, concentrated antibody medicines that can be easily reconstituted for injection, preventing degradation during freezing and storage.
- [How to Redesign Mouse Antibodies for Safe Use in Humans](https://patentbrief.org/patent/us/6054297/rituxan-chop-chemotherapy) — granted 2000
  Genentech's 1995 patent on a systematic method for humanizing rodent antibodies by grafting their disease-targeting loops onto a human consensus framework while carefully swapping key structural support residues to maintain binding strength.
- [Making Hybrid Antibodies from Different Animals](https://patentbrief.org/patent/us/4816567/recombinant-antibody-production-in-cho-cells) — granted 1989
  This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.
- [How Scientists Taught Bacteria to Make Human Hormones](https://patentbrief.org/patent/us/4356270/recombinant-dna-cloning-genentech) — granted 1982
  Genentech's 1979 patent on using engineered DNA to force bacteria to produce human proteins like insulin and growth hormones.

**Full profile:** https://patentbrief.org/company/genentech-inc

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_Source: PatentBrief — https://patentbrief.org. Plain-English explanations of US patents._